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Avsar Plus Tablet 160/10/12.5mg, 28 Ct - PharmEvo Eye Drops Twist up productThe combination of amlodipine, hydrochlorothiazide, and valsartan in this tablet has a synergistic effect on lowering blood pressure. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into smooth muscle cells, leading to vasodilation and reduced peripheral resistance. Hydrochlorothiazide, a thiazide diuretic, increases urinary excretion of sodium and water, which decreases blood volume and reduces blood pressure. Composition